Epidemiological Profile and Contact Patterns of Leprosy in Children Under 15 Years: A Verified Pediatric Evidence Synthesis

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Renni Yuniati
Universitas Diponegoro
Farah Chilwa Hidayati
Universitas Diponegoro
Muhammad Auzinal Haq
Universitas Diponegoro

Leprosy in children under 15 years remains an important epidemiological indicator because it reflects ongoing transmission, delayed diagnosis, or persistent exposure within communities. Understanding pediatric case profiles and contact patterns is essential for strengthening surveillance and early detection strategies. This study aimed to describe the epidemiological profile of pediatric leprosy cases and identify reported contact patterns among children younger than 15 years in an urban Brazilian setting, including age distribution, sex, operational classification, and household or social contact categories. The study employed a verified pediatric evidence synthesis using a publicly accessible full-text study from Salvador, Brazil. Data were extracted from registered pediatric leprosy cases during 2007–2011, focusing on demographic characteristics, clinical classification, and reported exposure categories. The analysis used descriptive frequencies and percentages because the source study did not include a non-case comparison group. Among 145 registered pediatric cases, 76 children were interviewed. Household contact was reported by 52.6% of children, social contact by 25.0%, combined contact by 5.2%, and unknown or no contact by 17.1%. Most cases occurred among children aged 10–14 years (59.3%), while paucibacillary disease represented 60.7% of cases and multibacillary disease 39.3%. The findings highlight the importance of integrated pediatric leprosy surveillance that includes household examination, attention to social and neighborhood exposure, and active case detection. However, the results should be interpreted as descriptive evidence because causal relationships and comparative risks require studies with appropriate control groups.


Keywords: pediatric leprosy, Mycobacterium leprae, contact patterns, epidemiological surveillance, evidence synthesis
Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Liu, X., Wei, L., Truelove, S. A., & Zhang, T. (2020). Epidemiology and transmission of COVID-19 in 391 cases and 1,286 of their close contacts in Shenzhen, China: A retrospective cohort study. The Lancet Infectious Diseases, 20(8), 911–919.
Brown, S. M., Rienks, S., McCrae, J. S., & Watamura, S. E. (2019). The co-occurrence of adverse childhood experiences among children investigated for child maltreatment: A latent class analysis. Child Abuse & Neglect, 87, 18–27.
Cordery, R., Purba, A. K., Begum, L., Mills, E., Mosavie, M., Vieira, A., Jauneikaite, E., Leung, R. C. Y., Siggins, M. K., & Ready, D. (2022). Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: A prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK. The Lancet Microbe, 3(5), e366–e375.
Fatunmbi, B. S., Taruc, A. Y., Sanikullah, K. H., Garfin, A. M. C., Belimac, J. G., Gatchalian, A. C., Valdez, M. R. D. J., Buado, C. A., Tejano, K. P., & Venida-Tablizo, A. (2026). Transmission interruption of leprosy in the Philippines: An update on the current program priorities and interventions. Tropical Medicine and Infectious Disease, 11(7), 192.
Glynn, J. R., & Moss, P. A. H. (2020). Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children. Scientific Data, 7(1), 329.
Hickie, I. B., Scott, E. M., Cross, S. P., Iorfino, F., Davenport, T. A., Guastella, A. J., Naismith, S. L., Carpenter, J. S., Rohleder, C., & Crouse, J. J. (2019). Right care, first time: A highly personalised and measurement-based care model to manage youth mental health. Medical Journal of Australia, 211, S3–S46.
Liu, Y., Gu, Z., Xia, S., Shi, B., Zhou, X.-N., Shi, Y., & Liu, J. (2020). What are the underlying transmission patterns of COVID-19 outbreak? An age-specific social contact characterization. EClinicalMedicine, 22.
Morgan, C., Webb, R. T., Carr, M. J., Kontopantelis, E., Green, J., Chew-Graham, C. A., Kapur, N., & Ashcroft, D. M. (2017). Incidence, clinical management, and mortality risk following self-harm among children and adolescents: Cohort study in primary care. BMJ, 359.
Morrison, F. (2015). ‘All over now?’ The ongoing relational consequences of domestic abuse through children’s contact arrangements. Child Abuse Review, 24(4), 274–284.
Pescarini, J. M., Strina, A., Nery, J. S., et al. (2018). Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases, 12(7), e0006622. https://doi.org/10.1371/journal.pntd.0006622
Reuter, A., Hughes, J., & Furin, J. (2019). Challenges and controversies in childhood tuberculosis. The Lancet, 394(10202), 967–978.
Santos, S. D., Penna, G. O., Costa, M. C. N., Natividade, M. S., & Teixeira, M. G. (2016). Leprosy in children and adolescents under 15 years old in an urban centre in Brazil. Memórias do Instituto Oswaldo Cruz, 111(6), 359–364. https://doi.org/10.1590/0074-02760160002
Shah, J. L., Scott, J., McGorry, P. D., Cross, S. P. M., Keshavan, M. S., Nelson, B., Wood, S. J., Marwaha, S., Yung, A. R., & Scott, E. M. (2020). Transdiagnostic clinical staging in youth mental health: A first international consensus statement. World Psychiatry, 19(2), 233–242.
Teixeira, C. S. S., Pescarini, J. M., Alves, F. J. O., et al. (2020). Incidence of and factors associated with leprosy among household contacts of patients with leprosy in Brazil. JAMA Dermatology, 156(6), 640–648. https://doi.org/10.1001/jamadermatol.2020.0772
Ungar, M. (2015). Practitioner review: Diagnosing childhood resilience—A systemic approach to the diagnosis of adaptation in adverse social and physical ecologies. Journal of Child Psychology and Psychiatry, 56(1), 4–17.
Ungar, M. (2019). Designing resilience research: Using multiple methods to investigate risk exposure, promotive and protective processes, and contextually relevant outcomes for children and youth. Child Abuse & Neglect, 96, 104098.
van Brakel, W. H., Warne, G., Cambau, E., Vedithi, S. C., Chukwu, J., Ebenso, J., Fenenga, C., Fiebig, L., Groenendijk, J., & Hambridge, T. (2024). Strategies for leprosy services in low-endemic areas and countries. Leprosy Review, 95(3), 0.
World Health Organization. (2018). Guidelines for the diagnosis, treatment and prevention of leprosy. World Health Organization, Regional Office for South-East Asia.
World Health Organization. (2021). Towards zero leprosy: Global leprosy (Hansen’s disease) strategy 2021–2030. World Health Organization.
World Health Organization. (2023). Interruption of transmission and elimination of leprosy disease.
Wright, C. F., FitzPatrick, D. R., & Firth, H. V. (2018). Paediatric genomics: Diagnosing rare disease in children. Nature Reviews Genetics, 19(5), 253–268.